-The recommended initial dose is 200 mg orally, followed in 6 to 12 hours by an additional dose of 200 or 400 mg orally, depending on the blood pressure response. -Thereafter, inpatient titration with labetalol hydrochloride tablets may proceed as follows : Tailoring drug selection according to individual patient characteristics can optimize the management and potential outcomes of patients with hypertensive emergency. Hypertensive Emergency. 20 mg IV over 2 minutes initially, then 40-80 mg IV q10min; total dose not to exceed 300 mg. Alternative: 1-2 mg/min by continuous IV infusion; total dose of 300 mg has been used Hypertensive emergency - definition: Severe hypertension that is associated with acute end-organ damage. Examples include malignant hypertension, with or without hypertensive encephalopathy, subarachnoid or intracerebral hemorrhage, acute pulmonary edema, aortic dissection, and rebound after withdrawal of antihypertensive medications. Labetalol consistently, in dose-related fashion, blunted increases in exercise-induced blood pressure and heart rate, and in their double product. The pulmonary circulation during exercise was not affected by Labetalol HCl dosing. May repeat or double labetalol every 10 min to maximum dose of 300 mg, or give initial labetalol dose, then Nicardipine 5 mg/h IV infusion as initial dose and titrate to desired effect by increasing 2. 5 mg/h every 5 nitroprusside or rule out other cause of acute hypertension such as hypertensive urgency. 1. Drug Intell Clin Pharm. 1987 Jun;21(6):512-4. Intravenous labetalol in the management of resistant hypertensive emergency. Ngole PM. A case of intravenous labetalol in the treatment of a resistant hypertensive emergency is reported. Oral nifedipine or intravenous labetalol for hypertensive emergency in pregnancy: a randomized controlled trial. Shekhar S(1), Sharma C, Thakur S, Verma S. Author information: (1)Departments of Obstetrics and Gynecology, AIIMS Jodhpur, Rajasthan, and Dr. Rajendra Prasad Government Medical College, Tanda, Kangra HP, India. Hypertensive crisis is a medical emergency requiring rapid blood pressure (BP) reduction to prevent or limit target organ damage. Treatment includes intensive monitoring and parenteral drug therapy. 1 Labetalol is a commonly used intravenous (i.v.) antihypertensive medication for treatment of a hypertensive emergency once end organ damage has.